Radula preparations are sold as cannabinoid-like legal high on the internet, even though pharmacological data are lacking. Phytochemical studies on the liverwort Radula genus have previously identified the bibenzyl (−)- cis-perrottetinene ( cis-PET), which structurally resembles (−)-Δ 9- trans-tetrahydrocannabinol (Δ 9- trans-THC) from Cannabis sativa L. Synthesis and characterization of products Profiling of THC and PET diastereoisomers on endocannabinoid-degrading enzymes in vitro. Representative LC-MS/MS reaction monitoring chromatogram of reference standards in mouse brain tissue showing LC separation of cis- and trans-PET. LC-MS/MS quantification of Δ9- trans-THC, cis-PET, and trans-PET in plasma of BALB/c male mice 1 hour after intraperitoneal injection of cannabinoids.įig. LC-MS/MS quantifications of the NAEs OEA, PEA, and LEA in the brain of BALB/c male mice 1 hour after intraperitoneal injection of cannabinoids.įig. GTPγS binding curves for THC and PET stereoisomers on human cannabinoid receptors.įig. Radioligand displacement assay using CP55,940 and membranes from CHO cells stably transfected with human CB1R and CB2R, respectively.įig. Supplementary material for this article is available at įig.
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